2 NPs mL-1) have been prepared inIzak-Nau et al. Particle and Fibre Toxicology 2013, ten:56 http://www.particleandfibretoxicology/content/10/1/Page 11 ofAcknowledgements This study was supported by the EU 7th Framework Programme, Marie Curie Actions, Network for Initial Training NanoTOES (PITN-GA-2010-264506), www.nanotoes.eu. The MALDI-TOF MS analyses have been carried out within the Proteomics and Bioinformatics facility from the Autonomous University of Barcelona (UAB), a member of ProteoRed-ISCIII network. The authors want to thank Dr. Matthew Boyles and Dr. Sonia Goy L ez for their helpful comments and ideas. Author specifics 1 Bayer Technology Services GmbH, Leverkusen 51368, Germany. 2 Division of Molecular Biology, University of Salzburg, Salzburg 5020, Austria.Primidone 3Catalan Institute of Nanotechnology (ICN), Campus UAB, Edifici CIN2, Barcelona 08193, Bellaterra, Spain. Received: 2 July 2013 Accepted: 1 November 2013 Published: 11 November 2013 References 1. Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price tag RE, Hazle JD, Halas NJ, West JL: Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci USA 2003, one hundred:135493554. two. Moghimi SM, Hunter AC, Murray JC: Nanomedicine: current status and future prospects. FASEB J 2005, 19:31130. three. Ravi Kumar MNV, Sameti M, Mohapatra SS, Kong X, Lockey RF, Bakowsky U, Lindenblatt G, Schmidt CH, Lehr M: Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J Nanosci Nanotechnol 2004, 4:87681. 4. Slowing II, Vivero-Escoto JL, Wu CW, Lin VS: Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 2008, 60:1278288. five. Vijayanathan V, Thomas T, Thomas TJ: DNA nanoparticles and development of DNA delivery vehicles for gene therapy. Biochemistry 2002, 41:140854094. six. He X, Wang K, Tan W, Liu B, Lin X, He C, Li D, Huang S, Li J: Bioconjugated nanoparticles for DNA protection from cleavage. J Am Chem Soc 2003, 125:7168169. 7. Tapec R, Zhao JX, Tan W: Development of organic dye-doped silica nanoparticle for bioanalysis and biosensors. J Nanosci Nanotechnol 2002, 2:40509.Diquafosol tetrasodium 8.PMID:35567400 Qhobosheane M, Santra S, Zhang P, Tan WH: Biochemically functionalized silica nanoparticles. Analyst 2001, 126:1274278. 9. Wang L, Tan WH: Multicolor FRET silica nanoparticles by single wavelength excitation. Nano Lett 2006, six:848. 10. Zhao JX, Tapec-Dytioco R, Tan WH: Ultrasensitive DNA detection utilizing highly fluorescent bioconjugated nanoparticles. J Am Chem Soc 2003, 125:114741475. 11. Zhao JX, Hilliard LR, Mechery SJ, Wang Y, Bagwe RP, Jin S, Tan W: A rapid bioassay for single bacterial cell quantitation employing bioconjugated nanoparticles. Proc Natl Acad Sci USA 2004, 101:150275032. 12. Walcarius A, Ganesan V: Ion-exchange properties and electrochemical characterization of quaternary ammonium-functionalized silica microspheres obtained by the surfactant template route. Langmuir 2006, 22:46977. 13. Han L, Sakamoto Y, Che S, Terasaki O: Insight into the defects of cage-type silica mesoporous crystals with Fd3m symmetry: TEM observations and a new proposal of `polyhedron packing’ for the crystals. Chemistry 2009, 15:81825. 14. Ow H, Larson DR, Srivastava M, Baird BA, Webb WW, Wiesner U: Vibrant and stable core-shell fluorescent silica nanoparticles. Nano Lett 2005, five:11317. 15. Mail der V, Landfester K: Interaction of nanoparticles with cells. Bi.
