Product Name :
HMN-154
Description:
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.
CAS:
173528-92-2
Molecular Weight:
366.43
Formula:
C20H18N2O3S
Chemical Name:
4-methoxy-N-{2-[(E)-2-(pyridin-4-yl)ethenyl]phenyl}benzene-1-sulfonamide
Smiles :
COC1C=CC(=CC=1)S(=O)(=O)NC1=CC=CC=C1/C=C/C1C=CN=CC=1
InChiKey:
CIJCDFMGZYKSSC-VOTSOKGWSA-N
InChi :
InChI=1S/C20H18N2O3S/c1-25-18-8-10-19(11-9-18)26(23,24)22-20-5-3-2-4-17(20)7-6-16-12-14-21-15-13-16/h2-15,22H,1H3/b7-6+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.|Product information|CAS Number: 173528-92-2|Molecular Weight: 366.43|Formula: C20H18N2O3S|Chemical Name: 4-methoxy-N-{2-[(E)-2-(pyridin-4-yl)ethenyl]phenyl}benzene-1-sulfonamide|Smiles: COC1C=CC(=CC=1)S(=O)(=O)NC1=CC=CC=C1/C=C/C1C=CN=CC=1|InChiKey: CIJCDFMGZYKSSC-VOTSOKGWSA-N|InChi: InChI=1S/C20H18N2O3S/c1-25-18-8-10-19(11-9-18)26(23,24)22-20-5-3-2-4-17(20)7-6-16-12-14-21-15-13-16/h2-15,22H,1H3/b7-6+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 15 mg/mL (40.94 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Islatravir} medchemexpress|{Islatravir} HIV|{Islatravir} Technical Information|{Islatravir} Purity|{Islatravir} supplier|{Islatravir} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{G15} site|{G15} Estrogen Receptor/ERR|{G15} Protocol|{G15} Purity|{G15} manufacturer|{G15} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32449406 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.|Products are for research use only. Not for human use.|
