Product Name :
Glabrescione B
Description:
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
CAS:
65893-94-9
Molecular Weight:
450.52
Formula:
C27H30O6
Chemical Name:
3-{3, 4-bis[(3-methylbut-2-en-1-yl)oxy]phenyl}-5, 7-dimethoxy-4H-chromen-4-one
Smiles :
COC1=CC(OC)=C2C(=O)C(=COC2=C1)C1C=C(OCC=C(C)C)C(=CC=1)OCC=C(C)C
InChiKey:
RHXDATRKLOYVTC-UHFFFAOYSA-N
InChi :
InChI=1S/C27H30O6/c1-17(2)9-11-31-22-8-7-19(13-23(22)32-12-10-18(3)4)21-16-33-25-15-20(29-5)14-24(30-6)26(25)27(21)28/h7-10,13-16H,11-12H2,1-6H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1.{{Azathioprine} site|{Azathioprine} Apoptosis|{Azathioprine} Protocol|{Azathioprine} Description|{Azathioprine} custom synthesis|{Azathioprine} Epigenetic Reader Domain} Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.|Product information|CAS Number: 65893-94-9|Molecular Weight: 450.52|Formula: C27H30O6|Chemical Name: 3-{3, 4-bis[(3-methylbut-2-en-1-yl)oxy]phenyl}-5, 7-dimethoxy-4H-chromen-4-one|Smiles: COC1=CC(OC)=C2C(=O)C(=COC2=C1)C1C=C(OCC=C(C)C)C(=CC=1)OCC=C(C)C|InChiKey: RHXDATRKLOYVTC-UHFFFAOYSA-N|InChi: InChI=1S/C27H30O6/c1-17(2)9-11-31-22-8-7-19(13-23(22)32-12-10-18(3)4)21-16-33-25-15-20(29-5)14-24(30-6)26(25)27(21)28/h7-10,13-16H,11-12H2,1-6H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (221.97 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clofibrate} web|{Clofibrate} Vitamin D Related/Nuclear Receptor|{Clofibrate} Technical Information|{Clofibrate} Formula|{Clofibrate} manufacturer|{Clofibrate} Autophagy} |Shelf Life: ≥360 days if stored properly.PMID:32468618 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma. Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels.|References:|Ingallina C, et al. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine (Lond). 2017;12(7):711-728.Infante P, et al. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J. 2015;34(2):200-217.Products are for research use only. Not for human use.|
