Product Name :
L-Ascorbic acid sodium salt
Description:
L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.
CAS:
134-03-2
Molecular Weight:
198.11
Formula:
C6H7NaO6
Chemical Name:
(5R)-5-[(1S)-1, 2-dihydroxyethyl]-3-hydroxy-4-(sodiooxy)-2, 5-dihydrofuran-2-one
Smiles :
OC1C(=O)O[C@H]([C@@H](O)CO)C=1O[Na]
InChiKey:
PPASLZSBLFJQEF-RXSVEWSESA-M
InChi :
InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.|Product information|CAS Number: 134-03-2|Molecular Weight: 198.11|Formula: C6H7NaO6|Synonym:|Sodium L-ascorbate|Vitamin C sodium salt|Chemical Name: (5R)-5-[(1S)-1, 2-dihydroxyethyl]-3-hydroxy-4-(sodiooxy)-2, 5-dihydrofuran-2-one|Smiles: OC1C(=O)O[C@H]([C@@H](O)CO)C=1O[Na]|InChiKey: PPASLZSBLFJQEF-RXSVEWSESA-M|InChi: InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 100 mg/mL (504.77 mM; Need ultrasonic) DMSO : 1 mg/mL (5.05 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5, 000.{{Ontuxizumab} MedChemExpress|{Ontuxizumab} Inhibitor|{Ontuxizumab} TGF-beta/Smad|{Ontuxizumab} Purity & Documentation|{Ontuxizumab} References|{Ontuxizumab} custom synthesis} |In Vivo:|Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.{{Baloxavir} web|{Baloxavir} Anti-infection|{Baloxavir} Biological Activity|{Baloxavir} Purity|{Baloxavir} manufacturer|{Baloxavir} Autophagy} 6%), compared to those without L-Ascorbic acid sodium salt (15.PMID:31686537 4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats.|References:|Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.Products are for research use only. Not for human use.|
