Product Name :
ACY-957
Description:
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
CAS:
1609389-52-7
Molecular Weight:
429.54
Formula:
C24H23N5OS
Chemical Name:
N-[2-amino-5-(thiophen-2-yl)phenyl]-2-(piperazin-1-yl)quinoline-6-carboxamide
Smiles :
NC1=CC=C(C=C1NC(=O)C1=CC=C2N=C(C=CC2=C1)N1CCNCC1)C1=CC=CS1
InChiKey:
VURDNNVAYZDGDK-UHFFFAOYSA-N
InChi :
InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.Betamethasone dipropionate manufacturer |Product information|CAS Number: 1609389-52-7|Molecular Weight: 429.Lumateperone manufacturer 54|Formula: C24H23N5OS|Chemical Name: N-[2-amino-5-(thiophen-2-yl)phenyl]-2-(piperazin-1-yl)quinoline-6-carboxamide|Smiles: NC1=CC=C(C=C1NC(=O)C1=CC=C2N=C(C=CC2=C1)N1CCNCC1)C1=CC=CS1|InChiKey: VURDNNVAYZDGDK-UHFFFAOYSA-N|InChi: InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.PMID:32116240 33 mg/mL (194.00 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors.|Products are for research use only. Not for human use.|
