Product Name :
HA130
Description:
HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.
CAS:
1229652-21-4
Molecular Weight:
463.29
Formula:
C24H19BFNO5S
Chemical Name:
(3-[4-(3-[(4-fluorophenyl)methyl]-2, 4-dioxo-1, 3-thiazolidin-5-ylidenemethyl)phenoxy]methylphenyl)boronic acid
Smiles :
OB(O)C1=CC(COC2C=CC(C=C3SC(=O)N(CC4C=CC(F)=CC=4)C3=O)=CC=2)=CC=C1
InChiKey:
VTNKMYWFWQTEHE-XKZIYDEJSA-N
InChi :
InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.|Product information|CAS Number: 1229652-21-4|Molecular Weight: 463.29|Formula: C24H19BFNO5S|Chemical Name: (3-[4-(3-[(4-fluorophenyl)methyl]-2, 4-dioxo-1, 3-thiazolidin-5-ylidenemethyl)phenoxy]methylphenyl)boronic acid|Smiles: OB(O)C1=CC(COC2C=CC(C=C3SC(=O)N(CC4C=CC(F)=CC=4)C3=O)=CC=2)=CC=C1|InChiKey: VTNKMYWFWQTEHE-XKZIYDEJSA-N|InChi: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 39 mg/mL (84.Rifaximin medchemexpress 18 mM).Saracatinib Src |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33146027 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation.|In Vivo:|HA130 slows T cell migration across lymph node HEVs. HA130 decreases the “outside HEVs/inside HEVs” ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs).|Products are for research use only. Not for human use.|
