Product Name :
NCT-502
Description:
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH.
CAS:
1542213-00-2
Molecular Weight:
395.45
Formula:
C18H20F3N5S
Chemical Name:
N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
Smiles :
CC1C=C(C)N=C(C=1)NC(=S)N1CCN(CC1)C1C=CC(=CN=1)C(F)(F)F
InChiKey:
HHKPPMSUPATMKP-UHFFFAOYSA-N
InChi :
InChI=1S/C18H20F3N5S/c1-12-9-13(2)23-15(10-12)24-17(27)26-7-5-25(6-8-26)16-4-3-14(11-22-16)18(19,20)21/h3-4,9-11H,5-8H2,1-2H3,(H,23,24,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH.|Product information|CAS Number: 1542213-00-2|Molecular Weight: 395.45|Formula: C18H20F3N5S|Chemical Name: N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide|Smiles: CC1C=C(C)N=C(C=1)NC(=S)N1CCN(CC1)C1C=CC(=CN=1)C(F)(F)F|InChiKey: HHKPPMSUPATMKP-UHFFFAOYSA-N|InChi: InChI=1S/C18H20F3N5S/c1-12-9-13(2)23-15(10-12)24-17(27)26-7-5-25(6-8-26)16-4-3-14(11-22-16)18(19,20)21/h3-4,9-11H,5-8H2,1-2H3,(H,23,24,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 130 mg/mL (328.Hypromellose Purity & Documentation 74 mM; Need ultrasonic).Omalizumab medchemexpress |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32119359 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NCT-502 is cytotoxic to MDA-MB-468, with an EC50 of 15.2 µM.|Products are for research use only. Not for human use.|
