Product Name :
(S)-(+)-Dimethindene maleate
Description:
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.8).
CAS:
136152-65-3
Molecular Weight:
408.49
Formula:
C24H28N2O4
Chemical Name:
(2Z)-but-2-enedioic acid; dimethyl(2-3-[(1S)-1-(pyridin-2-yl)ethyl]-1H-inden-2-ylethyl)amine
Smiles :
C[C@@H](C1C2=CC=CC=C2CC=1CCN(C)C)C1C=CC=CN=1.OC(=O)/C=C\C(O)=O
InChiKey:
SWECWXGUJQLXJF-HFNHQGOYSA-N
InChi :
InChI=1S/C20H24N2.Pentostatin Description C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Isocitric acid Cancer
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M1 (pA2 = 6.83/6.36; pKi = 7.08), the M3 (pA2 = 6.92/6.96; pKi = 6.70) and the M4 receptors (pKi = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.8).|Product information|CAS Number: 136152-65-3|Molecular Weight: 408.49|Formula: C24H28N2O4|Chemical Name: (2Z)-but-2-enedioic acid; dimethyl(2-3-[(1S)-1-(pyridin-2-yl)ethyl]-1H-inden-2-ylethyl)amine|Smiles: C[C@@H](C1C2=CC=CC=C2CC=1CCN(C)C)C1C=CC=CN=1.PMID:33023357 OC(=O)/C=C\C(O)=O|InChiKey: SWECWXGUJQLXJF-HFNHQGOYSA-N|InChi: InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|(S)-(+)-Dimethinden is an important regulator in the maintenance of EPS cell developmental potency.|In Vivo:|(S)-(+)-Dimethindene maleate shows affinity profile at muscarinic M1 (NB-OK 1 cells), M2 (rat heart), M3 (rat pancreas) and M4 receptors (rat striatum), with pKis 7.08, 7.78, 6.7 and 7,respectively.|Products are for research use only. Not for human use.|
