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Product Name :
Diethyl-pythiDC

Description:
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

CAS:
1821370-70-0

Molecular Weight:
306.34

Formula:
C14H14N2O4S

Chemical Name:
ethyl 6-[5-(ethoxycarbonyl)-1,3-thiazol-2-yl]pyridine-3-carboxylate

Smiles :
CCOC(=O)C1=CN=C(C=C1)C1=NC=C(S1)C(=O)OCC

InChiKey:
NSMODRMOSSBWGQ-UHFFFAOYSA-N

InChi :
InChI=1S/C14H14N2O4S/c1-3-19-13(17)9-5-6-10(15-7-9)12-16-8-11(21-12)14(18)20-4-2/h5-8H,3-4H2,1-2H3

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).|Product information|CAS Number: 1821370-70-0|Molecular Weight: 306.34|Formula: C14H14N2O4S|Chemical Name: ethyl 6-[5-(ethoxycarbonyl)-1,3-thiazol-2-yl]pyridine-3-carboxylate|Smiles: CCOC(=O)C1=CN=C(C=C1)C1=NC=C(S1)C(=O)OCC|InChiKey: NSMODRMOSSBWGQ-UHFFFAOYSA-N|InChi: InChI=1S/C14H14N2O4S/c1-3-19-13(17)9-5-6-10(15-7-9)12-16-8-11(21-12)14(18)20-4-2/h5-8H,3-4H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (108.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency.{{Nattokinase} MedChemExpress|{Nattokinase} Technical Information|{Nattokinase} In Vitro|{Nattokinase} custom synthesis|{Nattokinase} Epigenetic Reader Domain} MDA-MB-231 cells are treated with biheteroaryl dicarboxylates, and assayed for cytotoxicity and indicators of iron deficiency.{{CRISPR-Cas9 Protein, S. pyogenes} MedChemExpress|{CRISPR-Cas9 Protein, S. pyogenes} Biological Activity|{CRISPR-Cas9 Protein, S. pyogenes} Description|{CRISPR-Cas9 Protein, S. pyogenes} custom synthesis|{CRISPR-Cas9 Protein, S. pyogenes} Epigenetic Reader Domain} None of the esterified biheteroaryl dicarboxylates exhibited cytotoxic activity at high micromolar concentrations.PMID:32865111 Cells treated with dihydroxybenzoate (EDHB demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC (Diethyl pythiDC) appear to be normal at concentrations as high as 500 µM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin.|Products are for research use only. Not for human use.|

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Author: premierroofingandsidinginc