Product Name :
PF-00356231 hydrochloride
Description:
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.
CAS:
820223-77-6
Molecular Weight:
464.96
Formula:
C25H21ClN2O3S
Chemical Name:
(3R)-3-phenyl-3-(4-[4-(pyridin-4-yl)phenyl]thiophen-2-ylformamido)propanoic acid hydrochloride
Smiles :
Cl.OC(=O)C[C@@H](NC(=O)C1=CC(=CS1)C1C=CC(=CC=1)C1C=CN=CC=1)C1C=CC=CC=1
InChiKey:
AEKSZORLKGTXFF-VZYDHVRKSA-N
InChi :
InChI=1S/C25H20N2O3S.ClH/c28-24(29)15-22(20-4-2-1-3-5-20)27-25(30)23-14-21(16-31-23)18-8-6-17(7-9-18)19-10-12-26-13-11-19;/h1-14,16,22H,15H2,(H,27,30)(H,28,29);1H/t22-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.Ethacrynic acid Formula 4 μM).Imipramine Serotonin Transporter PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex.PMID:33297802 PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.|Product information|CAS Number: 820223-77-6|Molecular Weight: 464.96|Formula: C25H21ClN2O3S|Chemical Name: (3R)-3-phenyl-3-(4-[4-(pyridin-4-yl)phenyl]thiophen-2-ylformamido)propanoic acid hydrochloride|Smiles: Cl.OC(=O)C[C@@H](NC(=O)C1=CC(=CS1)C1C=CC(=CC=1)C1C=CN=CC=1)C1C=CC=CC=1|InChiKey: AEKSZORLKGTXFF-VZYDHVRKSA-N|InChi: InChI=1S/C25H20N2O3S.ClH/c28-24(29)15-22(20-4-2-1-3-5-20)27-25(30)23-14-21(16-31-23)18-8-6-17(7-9-18)19-10-12-26-13-11-19;/h1-14,16,22H,15H2,(H,27,30)(H,28,29);1H/t22-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH.|Products are for research use only. Not for human use.|
