Product Name :
Rabbit anti-Lamin B Polyclonal Antibody
Synonym :
LMNB1; Lamin-B1
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Lamin B Antibody detects endogenous levels of total Lamin B.
Predicted Reactivity:
Pig, Bovine, Sheep, Rabbit
Applications :
WB 1:500-1:2000, IHC 1:50-1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000
Immunogen:
A synthesized peptide derived from human Lamin B1.
Concentration :
1mg/ml
Purification :
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality:
Monoclonal Antibody
Storage Temp.:
Store at -20 ° C for one yearAvoid repeated freeze/that cycles
Research areas :
Background :
Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. It is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer). It is also a potential tumor marker as well as drug target [PMID: 30499270].
UniProt :
P20700
Additional information:
Product Details FAQ Citations(7) Video Pictures Documents |Overview |Description Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. |Synonym LMNB1; Lamin-B1 |Host Rabbit |Specificity Lamin B Antibody detects endogenous levels of total Lamin B. |Species Reactivity Human, Mouse, Rat |Predicted Reactivity Pig, Bovine, Sheep, Rabbit |Applications WB 1:500-1:2000, IHC 1:50-1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000 |Immunogen A synthesized peptide derived from human Lamin B1. |Properties |Form Liquid |Concentration 1mg/ml |Purification The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |Clonality Monoclonal Antibody |Clone 307-108 |Storage Temp. Store at -20 ° C for one yearAvoid repeated freeze/that cycles |Storage Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |Target |Background Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. It is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer). It is also a potential tumor marker as well as drug target [PMID: 30499270]. |Post-translational modifications B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. |Cellular localization Cytoskeleton;Nucleus; |UniProt P20700 | Western blot analysis of Lamin B expression in COLO cells |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-Lamin B1 Recombinant Monoclonal Antibody(307-108)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
2138440-82-9 Description 1640282-42-3 Purity & Documentation PMID:29999761 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
